Total number of publications: 120
2016-2020
1. Yu Cho Woo, Bin Gao, Chi Ho Lee, Carol Ho‐yi Fong, David Tak‐wai, Lui Jie Ming, Li Wang, Kristy Man‐yi Yeung, Bernard Man‐yung Cheung, Tai Hing Lam, Edward Janus, Qiuhe Ji, Karen Siu‐ling Lam. A 3-component non-invasive risk score for undiagnosed diabetes in Chinese: development, validation and longitudinal evaluation. Journal of Diabetes Investigation 2019;11:341-348
2. Chi-Ho Lee, Ruth S. M. Chan, Helen Y. L. Wan, Yu-Cho Woo, Chloe Y. Y. Cheung, Carol H. Y. Fong, Bernard M. Y. Cheung, Tai-Hing Lam, Edward Janus, Jean Woo, Karen S. L. Lam. Dietary Intake of Anti-Oxidant Vitamins A, C, and E Is Inversely Associated with Adverse Cardiovascular Outcomes in Chinese-A 22-Years Population-Based Prospective Study. Nutrients 2018;10: 1664
3. Paul C. H. Lee, Y. C. Woo, and Karen S. L. Lam. Fighting the Health Challenges of Diabetes in Hong Kong: A Window Into Mainland China. American journal of public health 2018;108:1623-1624
4. Bernard MY Cheung, CH Cheng, CP Lau, Chris KY Wong, Ronald CW Ma, Daniel WS Chu, Duncan HK Ho, Kathy LF Lee, HF Tse, Alexander SP Wong, Bryan PY Yan, Victor WT Yan. 2016 Consensus statement on prevention of atherosclerotic cardiovascular disease in the Hong Kong population. Hong Kong medical journal 2017;23:191-201
5. Chloe Y. Y. Cheung, Clara S. Tang, Aimin Xu, Chi-Ho Lee, Ka-Wing Au, Lin Xu, Carol H. Y. Fong, Kelvin H. M. Kwok, Wing-Sun Chow, Yu-Cho Woo, Michele M. A. Yuen, JoJo S. H. Hai, Ya-Li Jin, Bernard M. Y. Cheung, Kathryn C. B. Tan, Stacey S. Cherny, Feng Zhu, Tong Zhu, G. Neil Thomas, Kar-Keung Cheng, Chao-Qiang Jiang, Tai-Hing Lam, Hung-Fat Tse, Pak-Chung Sham, Karen S. L. Lam. Exome-chip association analysis reveals an Asian-specific missense variant in PAX4 associated with type 2 diabetes in Chinese individuals. Diabetologia 2017;60:107-115
6. Chloe Y.Y. Cheung, Clara S. Tang, Aimin Xu, Chi-Ho Lee, Ka-Wing Au, Lin Xu, Carol H.Y. Fong, Kelvin H.M. Kwok, Wing-Sun Chow, Yu-Cho Woo, Michele M.A. Yuen, Stacey S. Cherny, JoJo Hai, Bernard M.Y. Cheung, Kathryn C.B. Tan, Tai-Hing Lam, Hung-Fat Tse, Pak-Chung Sham, Karen S.L. Lam. An Exome-Chip Association Analysis in Chinese Subjects Reveals a Functional Missense Variant of GCKR That Regulates FGF21 Levels. Diabetes 2017;66:1723-28
7. Xiangfeng Lu, Gina M Peloso, Dajiang J Liu, Ying Wu, He Zhang, Wei Zhou, Jun Li, Clara Sze-man Tang, Rajkumar Dorajoo, Huaixing Li, Jirong Long, Xiuqing Guo, Ming Xu, Cassandra N Spracklen, Yang Chen, Xuezhen Liu, Yan Zhang, Chiea Chuen Khor, Jianjun Liu, Liang Sun, Laiyuan Wang, Yu-Tang Gao, Yao Hu, Kuai Yu, Yiqin Wang, Chloe Yu Yan Cheung, Feijie Wang, Jianfeng Huang, Qiao Fan, Qiuyin Cai, Shufeng Chen, Jinxiu Shi, Xueli Yang, Wanting Zhao, Wayne H-H Sheu, Stacey Shawn Cherny, Meian He, Alan B Feranil, Linda S Adair, Penny Gordon-Larsen, Shufa Du, Rohit Varma, Yii-Der Ida Chen, Xiao-Ou Shu, Karen Siu Ling Lam, Tien Yin Wong, Santhi K Ganesh, Zengnan Mo, Kristian Hveem, Lars G Fritsche, Jonas Bille Nielsen, Hung-fat Tse, Yong Huo, Ching-Yu Cheng, Y Eugene Chen, Wei Zheng, E Shyong Tai, Wei Gao, Xu Lin, Wei Huang, Goncalo Abecasis, GLGC Consortium, Sekar Kathiresan, Karen L Mohlke, Tangchun Wu, Pak Chung Sham, Dongfeng Gu, Cristen J Willer. Exome chip meta-analysis identifies novel loci and East Asian–specific coding variants that contribute to lipid levels and coronary artery disease. Nat Genet 2017;49:1722-1730
8. Yu Cho Woo, Chi Ho Lee, Carol H. Y. Fong, Annette W. K. Tso, Bernard M.Y. Cheung, Karen S. L. Lam. Validation of the diabetes screening tools proposed by the American Diabetes Association in an aging Chinese population. PLoS ONE 2017;12:e0184840
9. Yu Cho Woo, Chi Ho Lee, Carol H.Y. Fong, Aimin Xu, Annette W.K. Tso, Bernard M.Y. Cheung, Karen S.L. Lam. Serum fibroblast growth factor 21 is a superior biomarker to other adipokines in predicting incident diabetes. Clinical Endocrinology 2017;86:37-43
10. C. H. Lee, A. Z. L. Shih, Y. C. Woo, C. H. Y. Fong, O. Y. Leung, E. Janus, B. M. Y. Cheung and K. S. L. Lam. Optimal Cut-Offs of Homeostasis Model Assessment of Insulin Resistance (HOMA-IR) to Identify Dysglycemia and Type 2 Diabetes Mellitus: A 15-Year Prospective Study in Chinese. PLoS One 2016;11:e0163424
2011-2015
1. Clara S. Tang, He Zhang, Chloe Y. Y. Cheung, Ming Xu, Jenny C. Y. Ho, Wei Zhou, Stacey S. Cherny, Yan Zhang, Oddgeir Holmen, Ka-Wing Au, Haiyi Yu, Lin Xu, Jia Jia, Robert M. Porsch, Lijie Sun, Weixian Xu, Huiping Zheng, Lai-Yung Wong, Yiming Mu, Jingtao Dou, Carol H. Y. Fong, Shuyu Wang, Xueyu Hong, Liguang Dong, Yanhua Liao, Jiansong Wang, Levina S. M. Lam, Xi Su, Hua Yan, Min-Lee Yang, Jin Chen, Chung-Wah Siu, Gaoqiang Xie, Yu-Cho Woo, Yangfeng Wu, Kathryn C. B. Tan, Kristian Hveem, Bernard M. Y. Cheung, Sebastian Zöllner, Aimin Xu, Y Eugene Chen, Chao Qiang Jiang, Youyi Zhang, Tai-Hing Lam, Santhi K. Ganesh, Yong Huo, Pak C. Sham, Karen S. L. Lam, Cristen J. Willer, Hung-Fat Tse & Wei Gao. Exome-wide association analysis reveals novel coding sequence variants associated with lipid traits in Chinese. Nature Communications 2015;6: 10206
2. Chi Ho Lee, Yu Cho Woo, Joanne K.Y. Lam, Carol H.Y. Fong, Bernard M.Y. Cheung, Karen S.L. Lam, Kathryn C.B. Tan. Validation of the Pooled Cohort equations in a long-term cohort study of Hong Kong Chinese. J Clin Lipidol 2015;9:640-6 e2
3. C. H. Lee, Y. C. Woo, Y. Wang, C. Y. Yeung, A. Xu and K. S. L. Lam. Obesity, adipokines and cancer: an update. Clinical Endocrinology 2015;83:147-156
4. Y. C. Woo, B. M. Y. Cheung, C. Y. Yeung, C. H. Lee, E. Y. L. Hui, C. H. Y. Fong, A. W. K. Tso, S. Tam, K. S. L. Lam. Cardiometabolic risk profile of participants with prediabetes diagnosed by HbA1c criteria in an urban Hong Kong Chinese population over 40 years of age. Diabetic Medicine 2015;32:1207-1211
5. Chloe Y Y Cheung, Elaine Y L Hui, Bernard M Y Cheung, Y C Woo, Aimin Xu, Carol H Y Fong, K L Ong, C Y Yeung, Edward D Janus, Hung-Fat Tse, Pak C Sham and Karen S L Lam. Adiponectin gene variants and the risk of coronary heart disease: a 16-year longitudinal study. Eur J Endocrinol 2014;171:107-15
6. Elaine Hui, Aimin Xu, Wing-Sun Chow, Paul C.H. Lee, Carol H.Y. Fong, Stephen C.W. Cheung, Hung Fat Tse, Ming-Tak Chau, Bernard M.Y. Cheung, and Karen S.L. Lam. Hypoadiponectinemia As an Independent Predictor for the Progression of Carotid Atherosclerosis: A 5-Year Prospective Study. Metabolic Syndrome and Related Disorders 2014;12:517-522
7. Wing Sun Chow, Annette Wai Kwan Tso, Aimin Xu, Michele Mae Ann Yuen, Carol Ho Yi Fong, Tai Hing Lam, Su Vui Lo, Hung Fat Tse, Yu Cho Woo, Chun Yip Yeung, Bernard Man Yung Cheung, Karen Siu Ling Lam. Elevated circulating adipocyte-fatty acid binding protein levels predict incident cardiovascular events in a community-based cohort: a 12-year prospective study. J Am Heart Assoc 2013;2:e004176
8. Wing Sun Chow, Aimin Xu, Yu Cho Woo, Annette W.K. Tso, Stephen C.W. Cheung, Carol H.Y. Fong, Hung Fat Tse, Ming Tak Chau, Bernard M.Y. Cheung, and Karen S.L. Lam. Serum Fibroblast Growth Factor-21 Levels Are Associated With Carotid Atherosclerosis Independent of Established Cardiovascular Risk Factors. Arteriosclerosis, Thrombosis, and Vascular Biology 2013;33:2454-2459
9. Xin Yi Leng, Xiang Yan Chen, Ping Chook, Li Xiong, Wen Hua Lin, Jing Yi Liu, Brian Tomlinson, G. Neil Thomas, Tai Hing Lam, Karen S.L. Lam, Bernard M.Y. Cheung, Ka Sing Wong. Association Between Metabolic Syndrome and Carotid Atherosclerosis: A Community-Based Study in Hong Kong. Metabolic Syndrome and Related Disorders 2013;11:19-114
10. Xin Yi Leng, Xiang Yan Chen, Ping Chook, Li Xiong, Wen Hua Lin, Jing Yi Liu, Brian Tomlinson, G. Neil Thomas, Tai Hing Lam, Karen S.L. Lam, Bernard M.Y. Cheung, Ka Sing Wong.Correlation of Large Artery Intracranial Occlusive Disease With Carotid Intima-Media Thickness and Presence of Carotid Plaque. Stroke 2013;44:68-72
11. Hoi Kin Wong, Kwok Leung Ong, Raymond Y. H. Leung, Tommy T. Cheung, Aimin Xu, Tai Hing Lam, Karen S. L. Lam, Bernard M. Y. Cheung. Plasma Level of Adrenomedullin Is Influenced by a Single Nucleotide Polymorphism in the Adiponectin Gene. PLoS ONE 2013;8: e70335
12. Bernard M Y Cheung, Kwok Leung Ong, Annette W K Tso, Raymond Y H Leung, Stacey S Cherny, Pak Chung Sham, Tai Hing Lam, Karen S L Lam, Investigators of Hong Kong Cardiovascular Risk Factor Prevalence Study. Plasma adrenomedullin level is associated with a single nucleotide polymorphism in the adiponectin gene. European Heart Journal 2013;34:P1573-P1573
13. Hoi Kin Wong, Kwok Leung Ong, Raymond Y H Leung, Tai Hing Lam, Graham Neil Thomas, Karen S L Lam, Bernard M Y Cheung. A single nucleotide polymorphism of interleukin-6 gene is related to plasma adrenomedullin levels. Clinical Endocrinology 2013;79:504-509
14. Hanieh Yaghootkar, Claudia Lamina, Robert A. Scott, Zari Dastani, Marie-France Hivert, Liling L. Warren, Alena Stancáková, Sarah G. Buxbaum, Leo-Pekka Lyytikäinen, Peter Henneman, Ying Wu, Chloe Y.Y. Cheung, James S. Pankow, Anne U. Jackson, Stefan Gustafsson, Jing Hua Zhao, Christie M. Ballantyne, Weijia Xie, Richard N. Bergman, Michael Boehnke, Fatiha el Bouazzaoui, Francis S. Collins, Sandra H. Dunn, Josee Dupuis, Nita G. Forouhi, Christopher Gillson, Andrew T. Hattersley, Jaeyoung Hong, Mika Kähönen, Johanna Kuusisto, Lyudmyla Kedenko, Florian Kronenberg, Alessandro Doria, Themistocles L. Assimes, Ele Ferrannini, Torben Hansen, Ke Hao, Hans Häring, Joshua W. Knowles, Cecilia M. Lindgren, John J. Nolan, Jussi Paananen, Oluf Pedersen, Thomas Quertermous, Ulf Smith, the GENESIS Consortium, the RISC Consortium, Terho Lehtimäki, Ching-Ti Liu, Ruth J.F. Loos, Mark I. McCarthy, Andrew D. Morris, Ramachandran S. Vasan, Tim D. Spector, Tanya M. Teslovich, Jaakko Tuomilehto, Ko Willems van Dijk, Jorma S. Viikari, Na Zhu, Claudia Langenberg, Erik Ingelsson, Robert K. Semple, Alan R. Sinaiko, Colin N.A. Palmer, Mark Walker, Karen S.L. Lam, Bernhard Paulweber, Karen L. Mohlke, Cornelia van Duijn, Olli T. Raitakari, Aurelian Bidulescu, Nick J. Wareham, Markku Laakso, Dawn M. Waterworth, Debbie A. Lawlor, James B. Meigs, J. Brent Richards, Timothy M. Frayling. Mendelian randomization studies do not support a causal role for reduced circulating adiponectin levels in insulin resistance and type 2 diabetes. Diabetes 2013;62(10):3589-98
15. Chun-Yip Yeung, Annette Wai-Kwan Tso, Aimin Xu, Yu Wang, Yu-Cho Woo, Tai-Hing Lam, SuVui Lo, Carol Ho-Yee Fong, Nelson Ming-Sang Wat, Jean Woo, Bernard Man-Yung Cheung, Karen Siu-Ling Lam. Pro-inflammatory adipokines as predictors of incident cancers in a Chinese cohort of low obesity prevalence in Hong Kong. PLoS One 2013;8:e78594
16. Cheng Chen, Annette W. K. Tso, Bernard M. Y. Cheung, Lawrence S. C. Law, K. L. Ong, Nelson M. S. Wat, Edward D. Janus, Aimin Xu, Karen S. L. Lam. Plasma concentration of pigment epithelium-derived factor is closely associated with blood pressure and predicts incident hypertension in Chinese: a 10-year prospective study. Clinical Endocrinology 2012;76:506-513
17. BMY Cheung, KL Ong, AWK Tso, RYH Leung, A Xu, SS Cherny, PC Sham, TH Lam, KSL Lam on behalf of the Investigators of the Hong Kong Cardiovascular. Risk Factor Prevalence Study. C-reactive protein as a predictor of hypertension in the Hong Kong Cardiovascular Risk Factor Prevalence Study (CRISPS) cohort. J Hum Hypertens 2012;26:108-16
18. Bernard Man Yung Cheung, Tommy Tsang Cheung. Challenges in the management of hypertension in Asia. European Heart Journal Supplements 2012;14:A37-A38
19. Xiaoyan Hui, Karen S L Lam, Paul M Vanhoutte, Aimin Xu. Adiponectin and cardiovascular health: an update. Br J Pharmacol 2012;165:574-590
20. H Li, T O Kilpeläinen, C Liu, J Zhu, Y Liu, C Hu, Z Yang, W Zhang, W Bao, S Cha, Y Wu, T Yang, A Sekine, B Y Choi, C S Yajnik, D Zhou, F Takeuchi, K Yamamoto, J C Chan, K R Mani, L F Been, M Imamura, E Nakashima, N Lee, T Fujisawa, S Karasawa, W Wen, C V Joglekar, W Lu, Y Chang, Y Xiang, Y Gao, S Liu, Y Song, S H Kwak, H D Shin, K S Park, C H D Fall, J Y Kim, P C Sham, K S L Lam, W Zheng, X Shu, H Deng, H Ikegami, G V Krishnaveni, D K Sanghera, L Chuang, L Liu, R Hu, Y Kim, M Daimon, K Hotta, W Jia, J S Kooner, J C Chambers, G R Chandak, R C Ma, S Maeda, R Dorajoo, M Yokota, R Takayanagi, N Kato, X Lin, R J F Loos. Association of genetic variation in FTO with risk of obesity and type 2 diabetes with data from 96,551 East and South Asians. Diabetologia 2012;55:981-95
21. Yu-Cho Woo, Annette W. K. Tso, Aimin Xu, Lawrence S. C. Law, Carol H. Y. Fong, Tai-Hing Lam, Su-Vui Lo, Nelson M. S. Wat, Bernard M. Y. Cheung, Karen S. L. Lam. Combined use of serum adiponectin and tumor necrosis factor-alpha receptor 2 levels was comparable to 2-hour post-load glucose in diabetes prediction. PLoS One 2012;7:e36868
22. Cheng Chen, Bernard M Y Cheung, Annette W K Tso, Yudong Wang, Lawrence S C Law, Kwok Leung Ong, Nelson M S Wat, Aimin Xu, Karen S L Lam. High plasma level of fibroblast growth factor 21 is an Independent predictor of type 2 diabetes: a 5.4-year population-based prospective study in Chinese subjects. Diabetes Care 2011;34:2113-5
23. Bernard M Y Cheung, Kwok Leung Ong, Annette W K Tso, Raymond Y H Leung, Stacey S Cherny, Pak Chung Sham, Tai Hing Lam, Karen S L Lam and on behalf of the Investigators of the Hong Kong Cardiovascular Risk Factor Prevalence Study. Plasma adrenomedullin level is related to a single nucleotide polymorphism in the adrenomedullin gene. European Journal of Endocrinology 2011;165:571-577
24. Bernard M Y Cheung, Kwok-Leung Ong, Annette W K Tso, Stacey S Cherny, Pak-Chung Sham, Tai-Hing Lam, Karen S L Lam. Gamma-glutamyl transferase level predicts the development of hypertension in Hong Kong Chinese. Clin Chim Acta 2011;412:1326-31
25. Bernard M Y Cheung, Kwok Leung Ong, Annette W K Tso, Raymond Y H Leung, Stacey S Cherny, Pak Chung Sham, G Neil Thomas, Tai Hing Lam, Karen S L Lam, Investigators of the Hong Kong Cardiovascular Risk Factor Prevalence Study. Relationship of plasma interleukin-6 and its genetic variants with hypertension in Hong Kong Chinese. Am J Hypertens 2011;24:1331-7
26. Chloe Y Y Cheung, Annette W K Tso, Bernard M Y Cheung, Aimin Xu, Carol H Y Fong, K L Ong, Lawrence S C Law, Nelson M S Wat, Edward D Janus, Pak C Sham, Karen S L Lam. The KCNJ11 E23K polymorphism and progression of glycaemia in Southern Chinese: a long-term prospective study. PLoS One 2011;6:e28598
27. Chloe Y Y Cheung, Annette W K Tso, Bernard M Y Cheung, Aimin Xu, K L Ong, Lawrence S C Law, Nelson M S Wat, Edward D Janus, Pak C Sham, Karen S L Lam. Genetic variants associated with persistent central obesity and the metabolic syndrome in a 12-year longitudinal study. Eur J Endocrinol 2011;164:381-8
28. Lawrence S.C.Law, Annette W.K.Tso, Sidney Tam, Nelson M.S. Wat, Bernard M.Y. Cheung, Karen S.L. Lam. Haemoglobin A1c is superior to fasting glucose in predicting the incidence of diabetes over 8 years among Chinese. Diabetes Research and Clinical Practice 2011;91:e53-e56
29. Mo Yin Mok, Chak Sing Lau, Sonny Sau Hin Chiu, Annette Wai Kwan Tso, Yi Lo, Lawrence Siu Chun Law, Ka Fung Mak, Woon Sing Wong, Peh Lan Khong, Karen Siu Ling Lam. Systemic sclerosis is an independent risk factor for increased coronary artery calcium deposition. Arthritis & Rheumatism 2011;63:1387-1395
30. K. L. Ong, A. W. K. Tso, A. Xu, L. S. C. Law, M. Li, N. M. S. Wat, K. A. Rye, T. H. Lam, B. M. Y. Cheung, K. S. L. Lam. Evaluation of the combined use of adiponectin and C-reactive protein levels as biomarkers for predicting the deterioration in glycaemia after a median of 5.4 years. Diabetologia 2011;54:2552-2560
31. Kwok Leung Ong, Chao Qiang Jiang, Bin Liu, Ya Li Jin, Annette W.K. Tso, Sidney Tam, Ka Sing Wong, Brian Tomlinson, Bernard M.Y. Cheung, Jie Ming Lin, Xiao Jun Yue, Karen S.L. Lam, Tai Hing Lam, Graham Neil Thomas. Association of a genetic variant in the apolipoprotein A5 gene with the metabolic syndrome in Chinese. Clinical Endocrinology 2011;74:206-213
32. Kwok-Leung Ong, Annette W K Tso, Stacey S Cherny, Pak-Chung Sham, Tai-Hing Lam, Karen S L Lam, Bernard M Y Cheung, Investigators of the Hong Kong Cardiovascular Risk Factor Prevalence Study. Role of genetic variants in the gene encoding lipocalin-2 in the development of elevated blood pressure. Clin Exp Hypertens 2011;33:484-91
33. Kwok Leung Ong, Annette W.K. Tso, Raymond Y.H. Leung, Stacey S. Cherny, Pak Chung Sham, Tai Hing Lam, Bernard M.Y. Cheung, Karen S.L. Lam. A genetic variant in the gene encoding adrenomedullin predicts the development of dysglycemia over 6.4 years in Chinese. Clinica Chimica Acta 2011;412:353-357
34. A.W.K. Tso, T.K.Y. Lam, A. Xu, K.H. Yiu, H.F. Tse, L.S.W. Li, L.S.C. Law, B.M.Y. Cheung, R.T.F. Cheung, K.S.L. Lam. Serum adipocyte fatty acid-binding protein associated with ischemic stroke and early death. Neurology 2011;76:1968-1975
35. Ruby Yu, Jean Woo, Ruth Chan, Aprille Sham, Suzanne Ho, Annette Tso, Bernard Cheung, Tai Hing Lam, Karen Lam. Relationship between dietary intake and the development of type 2 diabetes in a Chinese population: the Hong Kong Dietary Survey. Public Health Nutr. 2011;14:1133-1141
2006-2010
1. Chao Qiang Jiang, Bin Liu, Bernard MY Cheung, Tai Hing Lam, Jie Ming Lin, Ya Li Jin, Xiao Jun Yue, Kwok Leung Ong, Sidney Tam, Ka Sing Wong, Brian Tomlinson, Karen SL Lam & G Neil Thomas. A single nucleotide polymorphism in APOA5 determines triglyceride levels in Hong Kong and Guangzhou Chinese. European Journal of Human Genetics 2010;18:1255-1260
2. Cheng Chen, Annette W. K. Tso, Lawrence S. C. Law, Bernard M. Y. Cheung, K. L. Ong, Nelson M. S. Wat, Edward D. Janus, Aimin Xu, Karen S. L. Lam. Plasma level of pigment epithelium-derived factor is independently associated with the development of the metabolic syndrome in Chinese men: a 10-year prospective study. The Journal of clinical endocrinology and metabolism 2010;95:5074
3. Chloe Y. Y. Cheung, Annette W. K. Tso, Bernard M. Y. Cheung, Aimin Xu, K. L. Ong, Carol H. Y. Fong, Nelson M. S. Wat, Edward D. Janus, Pak C. Sham, Karen S. L. Lam. Obesity Susceptibility Genetic Variants Identified from Recent Genome-Wide Association Studies: Implications in a Chinese Population. The Journal of Clinical Endocrinology & Metabolism 2010;95:1395-1403
4. Kwok Leung Ong, Mingfang Li, Annette W K Tso, Aimin Xu, Stacey S Cherny, Pak Chung Sham, Hung Fat Tse, Tai Hing Lam, Bernard M Y Cheung, Karen S L Lam and on behalf of the Investigators of the
Hong Kong Cardiovascular Risk Factor Prevalence Study. Association of genetic variants in the adiponectin gene with adiponectin level and hypertension in Hong Kong Chinese. Eur J Endocrinol 2010;163:251-7
5. Kwok Leung Ong, Annette W. K. Tso, Stacey S. Cherny, Pak Chung Sham, Karen S. L. Lam, Chao Qiang Jiang, Neil G. Thomas, Tai Hing Lam, Bernard M. Y Cheung. A genetic variant in the gene encoding fibrinogen beta chain predicted development of hypertension in Chinese men. Thrombosis and haemostasis 2010;103:728-735
6. Bernard M. Y. Cheung, Mingfang Li, Kwok Leung Ong, Nelson M. S. Wat, Sidney Tam, Richard W. C. Pang, G. Neil Thomas, Jean Woo, Edward D. Janus, Chu Pak Lau, Tai Hing Lam, Karen S. L. Lam. High density lipoprotein-cholesterol levels increase with age in American women but not in Hong Kong Chinese women. Clinical Endocrinology 2009;70:561-568
7. Kwok Leung Ong, Raymond Y H Leung, Anna Babinska, Moro O Salifu, Yigal H Ehrlich, Elizabeth Kornecki, Louisa Y F Wong, Annette W K Tso, Stacey S Cherny, Pak Chung Sham, Tai Hing Lam, Karen S L Lam, Bernard M Y Cheung. Elevated Plasma Level of Soluble F11 Receptor/Junctional Adhesion Molecule-A (F11R/JAM-A) in Hypertension. American Journal of Hypertension 2009;22:500-505
8. C M Schooling, T H Lam, E D Janus, B J Cowling, G M Leung, Hong Kong Cardiovascular Risk Factor Prevalence Study Steering Committee. A socio‐historical hypothesis for the diabetes epidemic in Chinese—Preliminary observations from Hong Kong as a natural experiment. American Journal of Human Biology 2009;21:346-353
9. Dennis C. Y. Yeung, Karen S. L. Lam, Yu Wang, Annette W. K. Tso, Aimin Xu. Serum zinc-alpha2-glycoprotein correlates with adiposity, triglycerides, and the key components of the metabolic syndrome in Chinese subjects. The Journal of clinical endocrinology and metabolism 2009;94:2531
10. Bernard M.Y. Cheung, Kwok Leung Ong, Roberta V. Cheung, Louisa Y.F. Wong, Nelson M.S. Wat, Sidney Tam, Gabriel M. Leung, Chun Ho Cheng, Jean Woo, Edward D. Janus, Chu Pak Lau, Tai Hing Lam, Karen S.L. Lam. Association between plasma alkaline phosphatase and C-reactive protein in Hong Kong Chinese. Chem. Lab. Med. 2008;46:523-527
11. Bernard M.Y. Cheung, Nelson M.S. Wat, Annette W.K. Tso, Sidney Tam, G. Neil Thomas, Gabriel M. Leung, Hung Fat Tse, Jean Woo, Edward D. Janus, Chu Pak Lau, Tai Hing Lam, Karen S.L. Lam. Association between raised blood pressure and dysglycemia in Hong Kong Chinese. Diabetes Care 2008;31:1889-1891
12. Bernard M.Y Cheung, Nelson M.S Wat, Y. B Man, Sidney Tam, C. H Cheng, Gabriel M Leung, Jean Woo, Edward D Janus, C. P Lau, T. H Lam, Karen S.L Lam. Relationship Between the Metabolic Syndrome and the Development of Hypertension in the Hong Kong Cardiovascular Risk Factor Prevalence Study-2 (CRISPS2). American Journal of Hypertension 2008;21:17-22
13. Bernard M. Y. Cheung, Nelson M. S. Wat, Sidney Tam, G. Neil Thomas, Gabriel M. Leung, Chun Ho Cheng, Jean Woo, Edward D. Janus, Chu Pak Lau, Tai Hing Lam, Karen S. L. Lam. Components of the metabolic syndrome predictive of its development: a 6‐year longitudinal study in Hong Kong Chinese. Clinical Endocrinology 2008;68:730-737
14. F. W. Louisa, O. Kwok Leung, M. Y. C. Bernard, Y. H. L. Raymond, M. Yu Bun and L. Tai Hing. Polymorphisms of the Fibrinogen-Beta Gene are Related to 2-Hour Glucose Level after Oral Glucose Tolerance Test in Hong Kong Chinese. Disease Markers 2008;24:167-173
15. K. L. Ong, Raymond Y.H. Leung, Louisa Y.F. Wong, Stacey S. Cherny, P.C. Sham, T.H. Lam, Karen S.L. Lam, Bernard M.Y. Cheung. Association of a Polymorphism in the Lipin 1 Gene With Systolic Blood Pressure in Men. American Journal of Hypertension 2008;21:539-545
16. K. L. Ong, R. Y. H. Leung, L. Y. F. Wong, S. S. Cherny, P. C. Sham, T. H. Lam, K. S. L. Lam, B. M. Y. Cheung. Association of F11 receptor gene polymorphisms with central obesity and blood pressure. Journal of Internal Medicine 2008;263:322-332
17. NMS Wat, TH Lam, ED Janus, KSL Lam. Impaired glucose tolerance as a risk factor for diabetes mellitus and hypertension in the hong kong Chinese population: A 5-year prospective study. Hong Kong Medical Journal 2008;14:S20-S22
18. Dennis C.Y. Yeung, Yu Wang, Aimin Xu, Stephen C.W. Cheung, Nelson M.S. Wat, Daniel Y.T. Fong, Carol H.Y. Fong, M.T. Chau, Pak C. Sham, Karen S.L. Lam. Epidermal fatty-acid-binding protein: a new circulating biomarker associated with cardio-metabolic risk factors and carotid atherosclerosis. European Heart Journal 2008;29:2156-2163
19. Xinmei Zhang, Dennis C.Y. Yeung, Michal Karpisek, David Stejskal, Zhi-Guang Zhou, Feng Liu, Rachel L.C. Wong, Wing-Sun Chow, Annette W.K. Tso, Karen S.L. Lam and Aimin Xu. Serum FGF21 levels are increased in obesity and are independently associated with the metabolic syndrome in humans. Diabetes 2008;57:1246-1253
20. Bernard M.Y. Cheung, Nelson M.S. Wat, Yu Bun Man, Sidney Tam, G. Neil Thomas, Gabriel M. Leung, Chun Ho Cheng, Jean Woo, Edward D. Janus, Chu Pak Lau, Tai Hing Lam, and Karen S.L. Lam. Development of diabetes in Chinese with the metabolic syndrome: a 6-year prospective study. Diabetes care 2007;30:1430-1436
21. Wing-Sun Chow, Bernard M Y Cheung, Annette W K Tso, Aimin Xu, Nelson M S Wat, Carol H Y Fong, Liza H Y Ong, Sidney Tam, Kathryn C B Tan, Edward D Janus, Tai-Hing Lam, Karen S L Lam. Hypoadiponectinemia as a Predictor for the Development of Hypertension: A 5-Year Prospective Study. Hypertension 2007;49:1455-1461
22. Mary Schooling, Tai Hing Lam, G. Neil Thomas, Benjamin J. Cowling, Michelle Heys, Edward D. Janus, Gabriel M. Leung, for the Hong Kong Cardiovascular Risk Factor Prevalence Study Steering Committee. Growth Environment and Sex Differences in Lipids, Body Shape and Diabetes Risk. PLoS ONE 2007;2:e1070
23. Neil Thomas, C. Mary Schooling, Sarah M. McGhee, Sai‐Yin Ho, Bernard M. Y. Cheung, Nelson M. S. Wat, Edward D. Janus, Karen S. L. Lam, Tai Hing Lam, for the Hong Kong Cardiovascular Risk Factor Prevalence Study Steering Committee. Metabolic syndrome increases all-cause and vascular mortality: the Hong Kong Cardiovascular Risk Factor Study. Clinical Endocrinology 2007;66:666-671
24. Annette W.K. Tso, Aimin Xu, Pak C. Sham, Nelson M.S. Wat, Yu Wang, Carol H.Y. Fong, Bernard M.Y. Cheung, Edward D. Janus, and Karen S.L. Lam. Serum adipocyte fatty acid-binding protein as a new biomarker predicting the development of type 2 diabetes: a 10-year prospective study in a Chinese cohort. Diabetes care 2007;30:2667
25. Yu Wang, Karen S L Lam, Edward W Kraegen, Gary Sweeney, Jialiang Zhang, Annette WK Tso, Wing-Sun Chow, Nelson MS Wat, Jian Yu Xu, Ruby LC Hoo, Aimin Xu. Lipocalin-2 is an inflammatory marker closely associated with obesity, insulin resistance, and hyperglycemia in humans. Clinical chemistry 2007;53:34
26. J Woo, B Cheung, S Ho, A Sham & T H Lam. Influence of dietary pattern on the development of overweight in a Chinese population. European Journal of Clinical Nutrition 2007;62:480
27. Jian Yu Xu, Pak C. Sham, Aimin Xu, Annette W. K. Tso, Nelson M. S. Wat, King Yip Cheng, Carol H. Y. Fong, Edward D. Janus, Karen S. L. Lam. Resistin gene polymorphisms and progression of glycaemia in southern Chinese: a 5‐year prospective study. Clinical Endocrinology 2007;66:211-217
28. Aimin Xu, Annette W.K. Tso, Bernard M.Y. Cheung, Yu Wang, Nelson M.S. Wat, Carol H.Y. Fong, Dennis C.Y. Yeung, Edward D. Janus, Pak C. Sham, and Karen S.L. Lam. Circulating Adipocyte-Fatty Acid Binding Protein Levels Predict the Development of the Metabolic Syndrome: A 5-Year Prospective Study. Circulation 2007;115:1537-1543
29. C.Y. Yeung, A. Xu, C.W.S. Cheung, N.M.S. Wat, M.H. Yau, C.H.Y. Fong, M.T. Chau, and K.S.L. Lam. Serum Adipocyte Fatty Acid-Binding Protein Levels Were Independently Associated With Carotid Atherosclerosis. Arteriosclerosis, Thrombosis, and Vascular Biology 2007;27:1796-1802
30. B M Y Cheung, R Y H Leung, Y B Man, K L Ong, L Y F Wong, C P Lau & K S L Lam. Association of hypertension with single nucleotide polymorphisms in the quantitative trait locus for abdominal obesity-metabolic syndrome on chromosome 17. Hum. Hypertens. 2006;20:419-425
31. B. M. Y. Cheung. The new cardiovascular continuum. Hong Kong medical journal 2006;12:161-163
32. Kwok Leung Ong, Louisa Y.F. Wong, Yu Bun Man, Raymond Y.H. Leung, You-Qiang Song, Karen S.L. Lam, Bernard M.Y. Cheung. Haplotypes in the urotensin II gene and urotensin II receptor gene are associated with insulin resistance and impaired glucose tolerance. Peptides 2006;27:1659-1667
33. Richard W.C. Pang, Sidney Tam, Edward D. Janus, Simon T.S. Siu, Oliver C.K. Ma, T.H. Lam, Karen S.L. Lam. Plasma lipid, lipoprotein and apolipoprotein levels in a random population sample of 2875 Hong Kong Chinese adults and their implications (NCEP ATP-III, 2001 guidelines) on cardiovascular risk assessment. Atherosclerosis 2006;184:438-445
34. A. Patel, K.-C. Huang, E.D. Janus, T. Gill, B. Neal, P. Suriyawongpaisal, E. Wong, M. Woodward, R.P. Stolk. Is a single definition of the metabolic syndrome appropriate?—A comparative study of the USA and Asia. Atherosclerosis 2006;184:225-232
35. Rong Rong, Ya‐Xiong Tao, Bernard M. Y. Cheung, Aimin Xu, Grace C. N. Cheung, Karen S. L. Lam. Identification and functional characterization of three novel human melanocortin‐4 receptor gene variants in an obese Chinese population. Clinical Endocrinology 2006;65:198-205
36. G. Neil Thomas, S. M. McGhee, C. M. Schooling, S. Y. Ho, K. S. L. Lam, E. D. Janus, T. H. Lam & Hong Kong Cardiovascular Risk Factor Prevalence Study Steering Committee. Determinants of normoglycemia and contribution to cardiovascular risk factors in a Chinese population: the Hong Kong Cardiovascular Risk Factor Study. J Endocrinol Invest 2006;29:528-35
37. G. Neil Thomas, Sarah M. McGhee, Mary Schooling, Sai Yin Ho,
Karen S.L. Lam, Edward D. Janus, Tai Hing Lam, for the Hong Kong Cardiovascular Risk Factor Prevalence Study Steering Committee. Impact of sex-specific body composition on cardiovascular risk factors: the Hong Kong Cardiovascular Risk Factor Study. Metabolism 2006;55:563-569
38. G Neil Thomas, C Mary Schooling, Sarah M McGhee, Sai-Yin Ho, Bernard M Y Cheung, Nelson M Wat, Edward D Janus, Tai Hing Lam, Hong Kong Cardiovascular Risk Factor Prevalence Study Steering Committee. Identification of factors differentially associated with isolated impaired fasting glucose and isolated post-load impaired glucose tolerance: the Hong Kong Cardiovascular Risk Factor Study. Eur J Endocrinol 2006;155:623-32
39. A. W. K. Tso, P. C. Sham, N. M. S. Wat, A. Xu, B. M. Y. Cheung, R. Rong, C. H. Y. Fong, J. Y. Xu, K. K. Y. Cheng, E. D. Janus & K. S. L. Lam. Polymorphisms of the gene encoding adiponectin and glycaemic outcome of Chinese subjects with impaired glucose tolerance: a 5-year follow-up study. Diabetologia 2006;49:1806-1815
40. Annette W.K. Tso, Kathryn C.B. Tan, Nelson M.S. Wat, Edward D. Janus, Tai-Hing Lam, Karen S.L. Lam. Endothelial nitric oxide synthase G894T (Glu298Asp) polymorphism was predictive of glycemic status in a 5-year prospective study of Chinese subjects with impaired glucose tolerance. Metabolism 2006;55:1155-1158
41. Aimin Xu, Yu Wang, Jian Yu Xu, David Stejskal, Sidney Tam, Jialiang Zhang, Nelson MS Wat, Wai Keung Wong, Karen SL Lam. Adipocyte fatty acid-binding protein is a plasma biomarker closely associated with obesity and metabolic syndrome. Clinical chemistry 2006;52:405-413
2001-2005
1. BMY Cheung, RYH Leung, YB Man, LYF Wong and CP Lau. Association of essential hypertension with a microsatellite marker on chromosome 17. Journal of Human Hypertension 2005;19:407
2. G Neil Thomas, Sai-Yin Ho, Edward D Janus, Karen S L Lam, Anthony J Hedley, Tai Hing Lam, Hong Kong Cardiovascular Risk Factor Prevalence Study Steering Committee. The US National Cholesterol Education Programme Adult Treatment Panel III (NCEP ATP III) prevalence of the metabolic syndrome in a Chinese population. Diabetes Research and Clinical Practice 2005;67:251-257
3. A Xu, MCW Lam, KW Chan, Y Wang, JL Zhang, RLC Hoo, JY Xu, BY Chen, WS Chow, AWK Tso, KSL Lam. Angiopoietin-like protein 4 decreases blood glucose and improves glucose tolerance but induces hyperlipidemia and hepatic steatosis in mice. P Natl Acad Sci USA 2005;102:6086-91
4. E.D.Janus. Metabolic syndrome and its relevance to Asia. International Congress Series 2004;1262:535-537
5. Karen S.L. Lam, Aimin Xu, Nelson M.S. Wat, Annette W.K. Tso, Mary S.M. Ip. Obesity as the key player in the metabolic syndrome. International Congress Series 2004;1262:542-545
6. Neil Thomas, Sai‐Yin Ho, Karen S.L. Lam, Edward D. Janus, Anthony J. Hedley, Tai Hing Lam, Hong Kong Cardiovascular Risk Factor Prevalence Study Steering Committee. Impact of obesity and body fat distribution on cardiovascular risk factors in Hong Kong Chinese. Obesity research 2004;12:1805-1813
7. Sai Yin Ho, Tai Hing Lam, Richard Fielding, Edward Denis Janus. Smoking and perceived health in Hong Kong Chinese. Social Science & Medicine 2003;57:1761-1770
8. Ho SY, Lam TH, Janus ED, Hong Kong Cardiovascular Risk Factor Prevalence Study Steering Committee. Waist to stature ratio is more strongly associated with cardiovascular risk factors than other simple anthropometric indices. Annals of Epidemiology 2003;13:683-691
9. Mohsen Janghorbani, Sai Yin Ho, Tai Hing Lam, Edward Denis Janus. Prevalence and correlates of alcohol use: a population-based study in Hong Kong. Addiction 2003;98:215-224
10. Kathryn C.B. Tan, Nelson M.S. Wat, Sidney C.F. Tam, Edward D. Janus, T.H. Lam, and Karen S.L. Lam. C-reactive protein predicts the deterioration of glycemia in Chinese subjects with impaired glucose tolerance. Diabetes Care 2003;26:2323-8
11. J Woo, S C Ho, A Sham, M M Sea, K S L Lam, T H Lam & E D Janus . Diet and glucose tolerance in a Chinese population. European journal of clinical nutrition 2003;57:523-530
12. A Xu, Y Wang, H Keshav, LY Xu, KSL Lam, GJS Cooper. The fat-derived hormone adiponection alleviates alcoholic and non-alcoholic liver diseases in mice. J Clin Invest 2003;112:91-100
13. M Zhang, K C B Tan, W-Y Zhang, J-Yu Xu, N M S Wat, S S M Chung, E D Janus, K S L Lam. Effects of a promoter variation in the hepatic glucokinase gene on promoter activity and glucose tolerance in Southern Chinese subjects. Clinical Genetics 2003;63:232-234
14. E. D. Janus. Cardiovascular risk factor prevalence in Hong Kong. Hong Kong: Health Services Research Committee. 2002. Print.
15. Tai Hing Lam, Siu Fung Chung, Edward D. Janus, Chu Pak Lau , Anthony J. Hedley, Hon Wah Chan, Liang Chow, Kin Kwan Keung, Shu Kin Li. Smoking, Alcohol Drinking and Non-Fatal Coronary Heart Disease in Hong Kong Chinese. Annals of Epidemiology 2002;12:560-567
16. Ho SC, Chen YM, Woo JL, Leung SS, Lam TH, Janus ED. Sodium is the Leading Dietary Factor Associated with Urinary Calcium Excretion in Hong Kong Chinese Adults. Osteoporos Int 2001;12:723-731
17. S C Ho, Y M Chen, J L Woo, S S Leung, T H Lam, E D Janus. Association between simple anthropometric indices and cardiovascular risk factors. International Journal of Obesity 2001;25:1689
18. NMS Wat, TH Lam, ED Janus & KSL Lam. Central obesity predicts the worsening of glycemia in southern Chinese. International Journal of Obesity and Related Disorders 2001;25:1789-1793
19. J Woo, KS Woo, SSF Leung, P Chook, B Liu, R Ip, SC Ho, SW Chan, JZ Feng and DS Celermajer. The Mediterranean score of dietary habits in Chinese populations in four different geographical areas. European Journal of Clinical Nutrition 2001;55:215
1997-2000
1. E. D . Janus, N. M. S. Wat, K. S. L. Lam, C. S. Cockram, S. T. S. Siu, L. J. Liu, T. H. Lam, on behalf of the Hong Kong Cardiovascular Risk Factor Steering Committee. The prevalence of diabetes, association with cardiovascular risk factors and implications of diagnostic criteria (ADA 1997 and WHO 1998) in a 1996 community based population study in Hong Kong Chinese. Diabetic Medicine 2000;17:741-745
2. T H Lam, L J Liu, E D Janus, K S Lam, A J Hedley, Hong Kong Cardiovascular Risk Factor Prevalence Study Steering Committee. Fibrinogen, other cardiovascular risk factors and diabetes mellitus in Hong Kong: a community with high prevalence of Type 2 diabetes mellitus and impaired glucose tolerance. Diabetic Medicine 2000;17:798-806
3. T. H. Lam, L.J. Liu, E.D. Janus, C.P. Lau, A.J. Hedley, for the Hong Kong Cardiovascular Risk Factor Prevalence Study Steering Committee. Fibrinogen, angina and coronary heart disease in a Chinese population. Atherosclerosis 2000;149:443-449
4. K S Lam, O C Ma, N M Wat, L C Chan, E D Janus. Beta-fibrinogen gene G/A-455 polymorphism in relation to fibrinogen concentrations and ischaemic heart disease in Chinese patients with type II diabetes. Diabetologia 1999;42:1250-1253
5. T. H. Lam, L. J. Liu, E. D. Janus, C. Bourke and A. J. Hedley. The relationship between fibrinogen and other coronary heart disease risk factors in a Chinese population. Atherosclerosis 1999;143:405-413
6. J. Woo, S. S. F. Leung, S. C. Ho & S. M. Chan. Is there a typical Chinese diet and what are the health implications? Ecology of Food and Nutrition 1999;38:491-503
7. J Woo, SSF Leung, SC Ho, A Sham, TH Lam and ED Janus. Influence of educational level and marital status on dietary intake, obesity and other cardiovascular risk factors in a Hong Kong Chinese population. European Journal of Clinical Nutrition 1999;53:461
8. J Woo. Nutrition and health issues in the general Hong Kong population. Hong Kong medical journal 1998;4:383-388
9. J Woo, S. S. Leung, S. C. Ho, T. H. Lam, and E. D. Janus. Dietary intake and practices in the Hong Kong Chinese population. J Epidemiol Community Health 1998;52:631
10. E D Janus. Epidemiology of Cardiovascular Risk Factors in Hong Kong. Clinical and Experimental Pharmacology and Physiology 1997;24:987-988
11. E. D. Janus. The Hong Kong cardiovascular risk factor prevalence study, 1995-1996. Hong Kong: Dept. of Clinical Biochemistry, Queen Mary Hospital of Hong Kong. 1997. Print.
12. R W Pang, B Chen, E D Janus, K S Lam. Frequency distributions of plasma apolipoprotein(a) levels and phenotypes: a comparison between Southern and Northern Chinese populations. Chinese Med J (Engl) 1997;110:465-73
13. J. Woo, S.S.F. Leung, S.C. Ho, T.H. Lam, E.D. Janus. A food frequency questionnaire for use in the Chinese population in Hong Kong: Description and examination of validity. Nutrition Research 1997;17:1633-1641
14. J Woo, S S Leung, C W Lam, S C Ho, T H Lam, E D Janus. Plasma Total Antioxidant Capacity in an Adult Hong Kong Chinese Population. Clinical Biochemistry 1997;30:553-557
15. J Woo, S S Leung, S C Ho, A Sham, T H Lam, E D Janus. Dietary practices and lipid intake in relation to plasma lipid profile in Hong Kong Chinese. European Journal of Clinical Nutrition 1997;51:467
